BDBM243456 US9427440, 1

SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)N(C)CCOCCN(C)S(=O)(=O)NC5=O

InChI Key InChIKey=UOBYJVFBFSLCTQ-UHFFFAOYSA-N

Data  2 IC50  11 Kd  1 EC50  11 Koff  11 Kon

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 243456   

TargetGenome polyprotein [2420-3010](Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Janssen Ireland

US Patent
LigandPNGBDBM243456(US9427440, 1)
Affinity DataIC50:  38nMT: 2°CAssay Description:IC50 con1b were determined according to the method as described previously (Pauwels et al, 2007, J Virol 81:6909-19) using a primer-dependent transcr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein [2420-3010](Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Janssen Ireland

US Patent
LigandPNGBDBM243456(US9427440, 1)
Affinity DataKd:  4.40nMpH: 7.4 T: 2°CAssay Description:All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein [2420-3010](Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Janssen Ireland

US Patent
LigandPNGBDBM243456(US9427440, 1)
Affinity DataKon:  0.0000900M-1s-1 Koff:  2.00E+4s-1pH: 7.4 T: 2°CAssay Description:All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein [2420-3010](Hepatitis C virus genotype 1b (strain HC-J4) (HCV))
Janssen Ireland

US Patent
LigandPNGBDBM243456(US9427440, 1)
Affinity DataKd:  5.20nM Kon:  0.000100M-1s-1 Koff:  2.00E+4s-1pH: 7.4 T: 2°CAssay Description:All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein [2420-3010](Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Janssen Ireland

US Patent
LigandPNGBDBM243456(US9427440, 1)
Affinity DataKd:  4.40nM Kon:  0.0000900M-1s-1 Koff:  2.00E+4s-1pH: 7.4 T: 2°CAssay Description:All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein [2420-3010](Hepatitis C virus genotype 1b (strain HC-J4) (HCV))
Janssen Ireland

US Patent
LigandPNGBDBM243456(US9427440, 1)
Affinity DataIC50:  240nMpH: 7.5 T: 2°CAssay Description:Measurement of HCV NS5B polymerization activity was performed by evaluating the amount of radiolabeled GTP incorporated by the enzyme in a newly synt...More data for this Ligand-Target Pair
In DepthDetails US Patent